Positions for the 2018-19 Academic Year are now complete. This page will be updated in December for those in third year beginning September 2019.
SSP Project/Supervisor Selection:
Step 1: You will find all projects listed on our website http://dbms.queensu.ca/undergraduate/biochemistry/422 beginning Dec. 21, 2018. You will have an opportunity to go through them over the holidays to see where your interest is. Once you return in January you are encouraged to meet with faculty if you have questions about the lab and research project. It is not mandatory to meet with faculty and faculty will not be able to guarantee you will be selected to their lab.
Step 2: You can go to this document (https://docs.google.com/forms/d/1VxPqndTe_7XAFVAHx7FbVSQaFcaIeoBYopjWhAgGVEg) to rank your top three selections. The document will open on January 2, 2019 and close at noon on January 31, 2019. We will endeavor to do our best to give you one of your choices.
Step 3: You will know by February 15, 2019 who your supervisor will be and which project you will be working on.
Step 4: Once final marks in May have been received we will ensure that everyone meets the requirements to be in BCHM 421 and BCHM 422. PREREQUISITE: Level 4 and (registration in a BCHM Specialization Plan) and (a GPA of 2.9 in BCHM 313/3.0, BCHM 315/3.0, BCHM 316/3.0, BCHM 317/6.0, BCHM 218/3.0). Final approval will be complete by May 10, 2019.
Participating Faculty 2019-2020:
SUPERVISOR PROJECT TITLE
Abraham, Sheela #1 Extracellular Vesicle Biogenesis in Chronic Myeloid Leukaemia
Abraham, Sheela #2 How extracellular vesicles effect stem cell function in Chronic Myeloid Leukaemia
Allingham, John Investigating the roles of kinesin motors in genome plasticity of Candida albicans
Capicciotti, Chantelle Investigating Glycan-Protein Interactions in Cells with Photo-Crosslinking Probes
Chan, Edmond #1 Regulation of mitochondria fusion machinery by nutrient stress
Chan, Edmond #2 Role for mitochondria dynamics in cancer cell growth
Craig, Andrew Defining targets of tumour suppressor microRNAs in malignant melanoma
Craig, Andrew & Allingham, John Developing novel actin-targeting antibody drug conjugates for metastatic cancers
Davies, Peter #1 Discovery of new ligand-binding domains in bacterial adhesins
Davies, Peter #2 Discovery and characterization of new antifreeze proteins
Davies, Peter #3 Structure-function relationships in ice nucleation proteins
Davies, Peter #4 Structure, function and inhibition of the calcium-activated calpain-3 protease
Ghasemlou, Nader #1 Profiling circadian rhythms in sensory neuron
Ghasemlou, Nader #2 Dissecting the inflammatory component of spinal cord injury pain
Jia, Zongchao #1 Structure-guided inhibition of polyphosphate kinase in P. aeruginosa as a novel antivirulence approach
Jia, Zongchao #2 Polyphosphate biosynthesis as a virulence factor determinant in multi-drug resistant bacterial pathogens
Mueller, Christopher #1 A blood test for directing Immunotherapy in Lung Cancer
Mueller, Christopher #2 A blood test for Prostate Cancer, replacing PSA
Mueller, Christopher #3 A blood test for Breast Cancer, replacing mammography
Plaxton, William Molecular, regulatory, and functional properties of key enzymes of plant carbohydrate and phosphate metabolism
Ross, Avena Genome Guided Discovery of Marine Natural Products
Smith, Steven Engineering designer enzyme complexes for directed production of biomass-based high-value chemicals
Snedden, Wayne Investigating calcium signal transduction in plants
Wu, Gang & Smith, Steven Synthesis of 17O-labeled amino acids and their incorporation into proteins
Zechel, David #1 Biosynthesis of a Fluorinated Natural Product in Streptomyces calvus
Zechel, David #2 The mechanisms and substrate specificities of the phosphonate degrading enzymes PhnY and PhnZ
Participating Faculty 2018-2019:
SUPERVISOR PROJECT TITLE
Allingham, John Understanding and targeting kinesin motors in invasive human fungal pathogens
Chan, Edmond Regulation of mitochondria fusion machinery by nutrient stress
Côté, Graham Functional and structural studies on the α-kinase family of protein kinases
Craig, Andrew Defining targets of tumour suppressor microRNAs in malignant melanoma
Davies, Peter #1 Discovery of new ligand-binding domains in bacterial adhesins
Davies, Peter #2 Discovery and characterization of new antifreeze proteins
Davies, Peter #3 Engineering bacterial adhesins to have new binding affinities
Davies, Peter #4 Structure, function and inhibition of the calcium-activated calpain-3 protease
Funk, Colin Arginase in Health and Disease
Ghasemlou, NaderProfiling circadian rhythms in sensory neurons
Jia, Zongchao #1 Structure and functional characterization of eukaryotic elongation factor 2 kinase
Jia, Zongchao #2 Structure-based disruption of Type 2 secretion system of Pseudomonas aeruginosa for development of antibiotics
Lillicrap, David Extracellular role of the von Willebrand factor propeptide in Hemostasis
Mueller, Christopher #1 A blood test for Lung Cancer
Mueller, Christopher #2 A blood test for Pancreatic Cancer
Ormiston, Mark High throughput screening of inhibitory peptides targeting the interaction of BMP9 with the Activin type II receptor
Petitjean, Anne Refining guanine quadruplex binders
Petrof, Elaine TBD
Plaxton, William Plant Biochemistry & Molecular Biology
Ross, Avena Isolation and Investigation fo the Biosynthesis of Natural Products from marine bacteria
Smith, Steven Structural and functional analyses of transcriptional networks associated with B-cell development and cancer
Smith, Steven #2 Engineering designer enzyme complexes for directed production of biomass-based high-value chemicals
Snedden, Wayne Investigating calcium signal transduction in plants
Walia, Jagdeep Assessing the role of GM2A antagonism in causation of atherosclerosis
Zechel, David #1 The mechanisms and substrate specificities of the phosphonate degrading enzymes PhnY and PhnZ
Zechel, David #2 Biosynthesis of a Fluorinated Natural Product in Streptomyces calvus