This past week, Canadian medicine lost one of its greats. One of the fundamental tenets of medical education and practice today, is that treatment should be guided by evidence. It seems so logical and fundamental, and yet, the “science of evidence-based medicine” is relatively young. Arguably, the father of that science, David Sackett, just recently passed away at age 80. Ostensibly, Sackett was able to pioneer and champion the marriage of statistically based epidemiology with the practice of clinical medicine.